PhD, Lyberopoulou Anna
Education
Lyberopoulou Anna graduated Biology faculty in the National and Kapodistrian University of Athens, with expertise in Molecular Biology. She continued her MSc in Medical school in Molecular Medicine. She completed her PhD in Medical School, Molecular Biology department in September of 2017.
Description of expertise
The overall work of Lyberopoulou Anna is based on her expertise in molecular biology techniques mainly in cancer, diabetes and in general cellular stress responses. In particular, she expertise manly in PCR techniques (PCR, RFLP-PCR, RT-PCR, Nested PCR, Real Time-PCR and HRM Real time PCR for methylation analysis), but also in tissue culture handling and laboratory animals handling, in immuno-based methods (IF, IHC, Western, ELISA, IP and Co-IP), in FACS and microscope handling (fluorescence, confocal, brightfield etc). in her PhD she dedicated on the isolation and molecular characterization of Circulating Tumor Cells (CTCs). They comprise a rare population in blood of cancer patients that includes subpopulations such as epithelial origin cells, stem cell like cells and cells with EMT (Epithelial to Mesenchymal Transition) phenotype. The goal was to detect these subpopulations in order to further investigate their molecular profile (methylation and mutational profile), using an immunomagnetic method based on Quantum Dots nanoparticles. Thus, her research field refers to cancer research with the use of novel technologies, since in recent years several types of nanoparticulate drug formulations have made their way from basic research to late clinical development or even clinical practice. Her work has led to several publications in peer reviewed journals.
Publications
- Lyberopoulou A, Galanopoulos M, Aravantinos G, Theodoropoulos GE, Marinos E, Efstathopoulos EP, Gazouli M. Identification of Methylation Profiles of Cancer-related Genes in Circulating Tumor Cells Population. Anticancer Res. 2017;37(3):1105-1112.
- Lyberopoulou A., Efstathopoulos PE., Gazouli M. (2016) Nanotechnology‐Based Rapid Diagnostic Tests, Proof and Concepts in Rapid Diagnostic Tests and Technologies, Dr. Shailendra K. Saxena (Ed.), InTech, DOI: 10.5772/63908.
- Lyberopoulou A, Aravantinos G, Efstathopoulos EP, Nikiteas N, Bouziotis P, Isaakidou A, Papalois A, Marinos E, Gazouli M. Mutational analysis of circulating tumor cells from colorectal cancer patients and correlation with primary tumor tissue. PLoS One. 2015 Apr 22;10(4):e0123902
- Lyberopoulou A, Aravantinos G, Efstathopoulos EP, Nikiteas N, Bouziotis P, Isaakidou A, Papalois A, Marinos E, Gazouli M. Mutational analysis of circulating tumor cells from colorectal cancer patients and correlation with primary tumor tissue. PLoS One. 2015 22;10(4):e0123902.
- Lyberopoulou A., Gazouli M. Theranostic Nanoparticles in Cancer Imaging. J Mol Biol & Mol. Imaging. 2015; 2(2): 1017.
- Lyberopoulou A, Efstathopoulos E.P, Gazouli M. Nanodiagnostic and nanotherapeutic molecular platforms for cancer management. J Can Res Updates. 2015. DOI: 10.6000/1929-2279.2015.04.04.3
- Lampropoulou E, Lyberopoulou A, Charonis A. Reduced expression of ERp46 under diabetic conditions in β-cells and the effect of liraglutide. Metabolism 65 (2016) pp. 7-15. In press.
- Gazouli M, Bouziotis P, Lyberopoulou A, Ikonomopoulos J, Papalois A, Anagnou NP, Efstathopoulos EP. Quantum dots-bevacizumab complexes for in vivo imaging of tumors. In Vivo. 2014 Nov-Dec; 28(6):1091-5.
- Papaconstantinou IG, Manta A, Gazouli M, Lyberopoulou A, Lykoudis PM, Polymeneas G, Voros D. (2012) Expression of MicroRNAs in Patients With Pancreatic Cancer and Its Prognostic Significance. Pancreas. Jul 30. [Epub ahead of print]
- Gazouli M., Lyberopoulou A., Pericleous P., Rizos S., Aravantinos G., Nikiteas, Anagnou N.P., Efstathopoulos E.P. (2012) Development of a Simple and Sensitive Quantum Dot Labelled Magnetic Immunoassay Method for Circulating Colorectal Cancer Cell Detection, World J Gastroenterol.18(32):4419-26.
- Pericleous P, Gazouli M, Lyberopoulou A, Rizos S, Nikiteas N, Efstathopoulos EP. (2012) Quantum dots hold promise for early cancer imaging and detection. Int J Cancer. Aug 1; 131(3):519-28. doi: 10.1002/ijc.27528. PMID: 22411309
- Karakatsanis A, Papaconstantinou I, Gazouli M, Lyberopoulou A, Polymeneas G, Voros D. (2011) Expression of microRNAs, miR-21, miR-31, miR-122, miR-145, miR-146a, miR-200c, miR-221, miR-222, and miR-223 in patients with hepatocellular carcinoma or intrahepatic cholangiocarcinoma and its prognostic significance. Mol Carcinog. doi: 10.1002/mc.21864
